P300 event-related potential (ERP) signals are useful neurological biomarkers, and their accurate classification is important when studying the cognitive functions in patients with neurological disorders. While many studies have proposed models for classifying these signals, results have been inconsistent. As a result, a consensus has not yet been reached on the optimal model for this classification. In this study, we evaluated the performance of classic machine learning and novel deep learning methods for P300 signal classification in both within and across subject training scenarios across a dataset of 75 subjects. Although the deep learning models attained high attended event classification F1 scores, they did not outperform Stepwise Linear Discriminant Analysis (SWLDA) in the within-subject paradigm. In the across-subject paradigm, however, EEG-Inception was able to significantly outperform SWLDA. These results suggest that deep learning models may provide a general model that do not require subject-specific training and calibration in clinical settings.
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