Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates

Nucleic Acids Res. 1987 Feb 25;15(4):1353-61. doi: 10.1093/nar/15.4.1353.


The previously presented consensus sequence for eukaryotic translation initiation sites by Kozak was derived substantially from vertebrate mRNA sequences. Drosophila nuclear genes exhibit a significantly different translation start consensus sequence. These differences probably do not represent mechanistic differences in translation initiation inasmuch as both taxa exhibit identical preferences and restrictions at the crucial -3 position. Using more conservative criteria for the assignment of consensus the following consensus sequences were derived: vertebrate--CANCAUG and Drosophila--CAAAACAUG.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Base Sequence
  • Drosophila / genetics*
  • Genes*
  • Protein Biosynthesis*
  • RNA, Messenger / genetics*
  • Species Specificity
  • Vertebrates / genetics*


  • RNA, Messenger