Implications of stress-induced gene expression for hematopoietic stem cell aging studies

Nat Aging. 2024 Feb;4(2):177-184. doi: 10.1038/s43587-023-00558-z. Epub 2024 Jan 16.


A decline in hematopoietic stem cell (HSC) function is believed to underlie hematological shortcomings with age; however, a comprehensive molecular understanding of these changes is currently lacking. Here we provide evidence that a transcriptional signature reported in several previous studies on HSC aging is linked to stress-induced changes in gene expression rather than aging. Our findings have strong implications for the design and interpretation of HSC aging studies.

MeSH terms

  • Gene Expression / genetics
  • Hematopoietic Stem Cells* / metabolism