Positron Emission Tomography/Computed Tomography Transformation of Oncology: Melanoma and Skin Malignancies

Sze-Ting Lee; Natalia Kovaleva; Clare Senko; Damien Kee; Andrew M Scott

doi:10.1016/j.cpet.2023.12.009

Positron Emission Tomography/Computed Tomography Transformation of Oncology: Melanoma and Skin Malignancies

PET Clin. 2024 Apr;19(2):231-248. doi: 10.1016/j.cpet.2023.12.009. Epub 2024 Jan 16.

Authors

Sze-Ting Lee¹, Natalia Kovaleva², Clare Senko³, Damien Kee⁴, Andrew M Scott⁵

Affiliations

¹ Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Australia; Department of Medicine, University of Melbourne, Melbourne, Australia; Olivia Newton-John Cancer Research Institute, and La Trobe University, Heidelberg, Australia; Department of Surgery, University of Melbourne, Melbourne, Australia; School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia.
² Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Australia.
³ Olivia Newton-John Cancer Research Institute, and La Trobe University, Heidelberg, Australia; Department of Medical Oncology, Olivia Newton-John Cancer and Wellness Centre, Austin Health, Heidelberg, Australia.
⁴ Olivia Newton-John Cancer Research Institute, and La Trobe University, Heidelberg, Australia; Department of Medical Oncology, Olivia Newton-John Cancer and Wellness Centre, Austin Health, Heidelberg, Australia; Department of Medical Oncology, Peter MacCallum Cancer Center, Melbourne, Australia.
⁵ Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Australia; Department of Medicine, University of Melbourne, Melbourne, Australia; Olivia Newton-John Cancer Research Institute, and La Trobe University, Heidelberg, Australia. Electronic address: andrew.scott@onjcri.org.au.

PMID: 38233284
DOI: 10.1016/j.cpet.2023.12.009

Abstract

Skin cancers are the most common cancers, with melanoma resulting in the highest cause of death in this category. Accurate clinical, histologic, and imaging staging with fludeoxyglucose positron emission tomography (FDG PET) is most important to guide patient management. Whilst surgical excision with clear margins is the gold-standard treatment for primary cutaneous melanoma, targeted therapies have generated remarkable and rapid clinical responses in melanoma, for which FDG PET also plays an important role in assessment of treatment response and post-therapy surveillance. Non-FDG PET tracers, advanced PET technology, and PET radiomics may potentially change the landscape of the utilization of PET in the imaging of patients with cutaneous malignancies.

Keywords: Cutaneous malignancies; FDG-PET; Immunotherapy; Melanoma; PET; PET radiomics.

Publication types

Review

MeSH terms

Fluorodeoxyglucose F18
Humans
Melanoma* / diagnostic imaging
Neoplasm Staging
Positron Emission Tomography Computed Tomography / methods
Positron-Emission Tomography / methods
Radiopharmaceuticals
Skin Neoplasms* / diagnostic imaging
Skin Neoplasms* / therapy

Substances

Fluorodeoxyglucose F18
Radiopharmaceuticals