Recent progress in metabolic reprogramming in gestational diabetes mellitus: a review

Front Endocrinol (Lausanne). 2024 Jan 3:14:1284160. doi: 10.3389/fendo.2023.1284160. eCollection 2023.

Abstract

Gestational diabetes mellitus is a prevalent metabolic disease that can impact the normal course of pregnancy and delivery, leading to adverse outcomes for both mother and child. Its pathogenesis is complex and involves various factors, such as insulin resistance and β-cell dysfunction. Metabolic reprogramming, which involves mitochondrial oxidative phosphorylation and glycolysis, is crucial for maintaining human metabolic balance and is involved in the pathogenesis and progression of gestational diabetes mellitus. However, research on the link and metabolic pathways between metabolic reprogramming and gestational diabetes mellitus is limited. Therefore, we reviewed the relationship between metabolic reprogramming and gestational diabetes mellitus to provide new therapeutic strategies for maternal health during pregnancy and reduce the risk of developing gestational diabetes mellitus.

Keywords: blood glucose; gestational diabetes mellitus; metabolic reprogramming; mitochondrial oxidative phosphorylation; pathophysiology.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Diabetes, Gestational*
  • Female
  • Humans
  • Insulin Resistance*
  • Metabolic Reprogramming
  • Mothers
  • Pregnancy

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Science and Technology Bureau of Quanzhou (Grant Number 2020CT003), Fujian Provincial Key Clinical Specialties Construction Project in 2022 (The Second Affiliated Hospital of Fujian Medical University Key Discipline Special Project, Grant number:HLZDZK202301) and Startup Fund for scientific research, Fujian Medical University(Grant number:2022QH1119).