Nomogram for predicting prolonged postoperative ileus in colorectal cancer based on age and inflammatory markers

Biomark Med. 2023 Nov;17(22):921-933. doi: 10.2217/bmm-2023-0355. Epub 2024 Jan 18.

Abstract

Aim: To explore the relationship between inflammatory markers and prolonged postoperative ileus (PPOI), and to establish a nomogram for predicting PPOI. Patients & methods: The data of 229 patients were analyzed retrospectively. Univariate and multivariate logistic regression analysis were used to analyze the risk factors affecting the occurrence of PPOI. The predictive model of PPOI was established and verified internally. Results: Postoperative PPOI occurred in 87 (38.0%) of all 229 patients. Our study showed that age, preoperative neutrophil-lymphocyte ratio and changes in neutrophil-lymphocyte ratio were independent risk factors for PPOI. Conclusion: The nomograms established based on these independent risk factors have good predictive efficacy and may be able to guide clinicians to individualize the diagnosis and treatment.

Keywords: colorectal cancer; inflammatory biomarker; nomogram; prolonged postoperative ileus; risk factor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Colorectal Neoplasms* / complications
  • Colorectal Neoplasms* / surgery
  • Humans
  • Ileus* / diagnosis
  • Ileus* / epidemiology
  • Ileus* / etiology
  • Nomograms
  • Postoperative Complications / diagnosis
  • Postoperative Complications / etiology
  • Retrospective Studies
  • Risk Factors

Grants and funding