Structural features of Prussian Blue-related iron complex - FeT of activity to peroxidate unsaturated fatty acids

Nanomedicine (Lond). 2024 Feb;19(4):281-292. doi: 10.2217/nnm-2023-0206. Epub 2024 Jan 19.

Abstract

Aim: FeT is a complex of Fe3+, ferricyanide and tartrate, similar in structure to Prussian Blue. Its synthesis was planned to produce a potential antiproliferative drug. Methods: Dynamic light scattering was applied to study nanostructures formed by FeT complexes, while their biological activity was tested following changes in cell proliferation using cultured T24 human bladder cancer cells. Results: The antiproliferative activity of FeT derived from its ability to peroxidate unsaturated fatty acids, which can cause cell death through oxidative stress and/or ferroptosis. FeT molecules associate into drop-like nanostructures in water solutions, between 10-130 nm, which can bind albumin. Conclusion: Fatty acid peroxidation is significantly activated by light. The characteristics and reactivity of FeT represent a prospective application in medicine.

Keywords: Prussian Blue; ferroptosis; nanoparticles; peroxidation of fatty acids.

MeSH terms

  • Fatty Acids, Unsaturated
  • Ferrocyanides / chemistry
  • Humans
  • Iron* / chemistry
  • Nanostructures* / chemistry

Substances

  • Iron
  • ferric ferrocyanide
  • Fatty Acids, Unsaturated
  • Ferrocyanides