SKA3 targeted therapies in cancer precision surgery: bridging bench discoveries to clinical applications - review article

Int J Surg. 2024 Apr 1;110(4):2323-2337. doi: 10.1097/JS9.0000000000001123.

Abstract

Spindle and kinetochore-associated complex subunit 3 (SKA3) is a microtubule-binding subcomplex of the outer kinetochore, which plays a vital role in proper chromosomal segregation and cell division. Recently, SKA3 have been demonstrated its oncogenic role of tumorigenesis and development in cancers. In this review, the authors comprehensively deciphered SKA3 in human cancer from various aspects, including bibliometrics, pan-cancer analysis, and narrative summary. The authors also provided the top 10 predicted drugs targeting SKA3. The authors proposed that SKA3 was a potential target and brought new therapeutic opportunities for cancer patients.

Publication types

  • Review

MeSH terms

  • Cell Cycle Proteins*
  • Humans
  • Microtubule-Associated Proteins / metabolism
  • Molecular Targeted Therapy / methods
  • Neoplasms* / drug therapy
  • Neoplasms* / surgery
  • Precision Medicine / methods

Substances

  • Ska3 protein, human
  • Microtubule-Associated Proteins
  • Cell Cycle Proteins