A total of 231 women with mitral valvular disease at the stage of compensation were examined. An analysis of the complex of clinico-instrumental values of the functional state showed that the level of lowered physical working capacity was associated not only with disease type but also with functional reserves of the adaptation to exercise. Insufficiency of compensatory-adaptation reactions and lowered resources were revealed in the patients with a decreased tolerance to physical exercise. Among persons with low adaptation resources were mainly patients with mitral stenosis and its prevalence. Persons with high adaptation resources could do the work the energetic level of which reached a submaximum value.