A holistic view of the malignant organism we call glioblastoma

Salma Baig; Frank Winkler

doi:10.1016/j.cell.2023.12.021

A holistic view of the malignant organism we call glioblastoma

Cell. 2024 Jan 18;187(2):271-273. doi: 10.1016/j.cell.2023.12.021.

Authors

Salma Baig¹, Frank Winkler²

Affiliations

¹ Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: salma.baig@dkfz-heidelberg.de.
² Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: frank.winkler@med.uni-heidelberg.de.

PMID: 38242083
DOI: 10.1016/j.cell.2023.12.021

Abstract

Tumors are not simply a chaotic mass of mutated cells but can follow complex organizational principles, including in space. In this issue of Cell, Mathur and colleagues reconstruct a 3D genomic, epigenomic, and transcriptomic spatial cartograph of glioblastoma, offering a "whole-tumor" perspective with patterns of clonal expansion that are embedded in neurodevelopmental hierarchy.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Brain Neoplasms* / genetics
Brain Neoplasms* / pathology
Gene Expression Profiling
Glioblastoma* / genetics
Glioblastoma* / pathology
Humans
Transcriptome