A quick restart: RNA polymerase jumping onto post-replicative chromatin

Mol Cell. 2024 Jan 18;84(2):186-188. doi: 10.1016/j.molcel.2023.12.029.


Two recent studies in Molecular Cell1 and Nature2 show that evicted RNA polymerases reassociate rapidly with post-replicative chromatin and proceed into an unusual transcription cycle, bypassing regular controls and creating a temporary window for altered gene expression.

MeSH terms

  • Chromatin* / genetics
  • Chromosomes / metabolism
  • DNA Replication*
  • DNA-Directed RNA Polymerases / genetics
  • DNA-Directed RNA Polymerases / metabolism
  • Transcription, Genetic


  • Chromatin
  • DNA-Directed RNA Polymerases