Noncanonical translation of circRNAs drive antitumor immunity

Trends Cancer. 2024 Feb;10(2):100-102. doi: 10.1016/j.trecan.2024.01.006. Epub 2024 Jan 18.


Identifying tumor-specific antigenic peptides beyond mutational events is essential for developing effective antitumor immunotherapies. In a recent study, Huang et al. identified an immunogenic cryptic peptide encoded by the circular RNA circFAM53B, through integrating mass spectrometry and ribosome sequencing data from breast cancer samples, and demonstrated its antitumor immunogenicity.

Keywords: antitumor immunity; circular RNAs; noncanonical translation.

MeSH terms

  • Humans
  • Neoplasms* / genetics
  • Neoplasms* / therapy
  • RNA / genetics
  • RNA, Circular* / genetics


  • RNA, Circular
  • RNA