Sarcoidosis-Associated Pulmonary Hypertension

Clin Chest Med. 2024 Mar;45(1):185-197. doi: 10.1016/j.ccm.2023.08.007. Epub 2023 Sep 1.

Abstract

Pulmonary hypertension is a life-threatening complication of advanced sarcoidosis. Many mechanisms can cause an elevation of pulmonary pressure in sarcoidosis, leading to precapillary or postcapillary pulmonary hypertension. Sarcoidosis-associated pulmonary hypertension contributes to severe exertional dyspnea, reduced exercise capacity, and notably compromised the survival. Despite the critical functional and prognostic implications of pulmonary hypertension in sarcoidosis, there is a scarcity of specific guidelines on the management of these patients due to a lack of evidence. Hence, further research is required to identify subgroups of patients who may benefit from pulmonary arterial hypertension-targeted therapies and/or immunosuppressive therapies.

Keywords: Pulmonary hypertension; Sarcoidosis; Screening.

Publication types

  • Review

MeSH terms

  • Humans
  • Hypertension, Pulmonary* / etiology
  • Hypertension, Pulmonary* / therapy
  • Lung
  • Prognosis
  • Pulmonary Arterial Hypertension*
  • Sarcoidosis* / complications
  • Sarcoidosis, Pulmonary* / complications