Unselected donor-derived hematopoietic stem cells boost for Chimeric Antigen Receptor T-cell associated hematotoxicity

Eugenio Galli; Maria Assunta Limongiello; Elisabetta Metafuni; Sabrina Giammarco; Alberto Fresa; Nicola Piccirillo; Maria Bianchi; Luca Laurenti; Federica Sorà; Patrizia Chiusolo; Simona Sica

doi:10.1002/ajh.27208

Unselected donor-derived hematopoietic stem cells boost for Chimeric Antigen Receptor T-cell associated hematotoxicity

Am J Hematol. 2024 Apr;99(4):751-754. doi: 10.1002/ajh.27208. Epub 2024 Jan 22.

Authors

Eugenio Galli¹, Maria Assunta Limongiello¹, Elisabetta Metafuni¹, Sabrina Giammarco¹, Alberto Fresa^{1

2}, Nicola Piccirillo^{1

2}, Maria Bianchi¹, Luca Laurenti^{1

2}, Federica Sorà^{1

2}, Patrizia Chiusolo^{1

2}, Simona Sica^{1

2}

Affiliations

¹ Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
² Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Rome, Italy.

PMID: 38247313
DOI: 10.1002/ajh.27208

Abstract

Hematological toxicity following Chimeric Antigen Receptor-T therapy in a patient with a prior allogeneic stem cell transplantation was resolved by the infusion of unselected donor-derived stem cell boost. Due to the donor's lymphocytes, the patient experienced a well-controlled flare-up of acute graft versus host disease.

Publication types

Letter

MeSH terms

Graft vs Host Disease* / etiology
Hematopoietic Stem Cell Transplantation*
Hematopoietic Stem Cells
Humans
Receptors, Chimeric Antigen*
T-Lymphocytes
Transplantation, Homologous

Substances

Receptors, Chimeric Antigen