Extracorporal perfusion of the porcine xenospleen was used by the authors in 5 patients with purulent surgical diseases complicated by a septic reaction. Recovery was noted in 2 patients. In one of the patients the extracorporal perfusion of the xenospleen was used in a systemic lupus erythematosus complicated by vasculitic destruction of soft tissues with septic reaction. The effect was positive. The extracorporal perfusion of the porcine xenospleen is considered by the authors to be an effective method of detoxication of organism of patients with septic complications.