Manifestation of Pancytopenia Associated with COVID-19 as Paroxysmal Nocturnal Hemoglobinuria (PNH) and Aplastic Anemia (AA)

Jeff Justin Aguilar; Vikram Dhillon; Suresh Balasubramanian

doi:10.3390/hematolrep16010005

Manifestation of Pancytopenia Associated with COVID-19 as Paroxysmal Nocturnal Hemoglobinuria (PNH) and Aplastic Anemia (AA)

Hematol Rep. 2024 Jan 17;16(1):42-49. doi: 10.3390/hematolrep16010005.

Authors

Jeff Justin Aguilar¹, Vikram Dhillon², Suresh Balasubramanian²

Affiliations

¹ School of Medicine, Wayne State University, Detroit, MI 48201, USA.
² Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA.

Abstract

We report two cases of pancytopenia in patients after recovering from a mild COVID-19, now presenting as paroxysmal nocturnal hemoglobinuria (PNH) and aplastic anemia. These cases illustrate a common pathway whereby a viral trigger causes the clonal expansion of a hematological disorder. Although the association of both cases with COVID-19 is temporal and COVID-19 may be an incidental diagnosis, the growing evidence related to the hematological effects of SARS-CoV-2 infection highlights the need for further investigation into the hematological consequences of COVID-19, particularly in the post-pandemic era.

Keywords: SARS-CoV-2; aplastic anemia; paroxysmal nocturnal hemoglobinuria.

Publication types

Case Reports

Grants and funding

This research received no external funding.