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. 2024 Feb 23;87(2):266-275.
doi: 10.1021/acs.jnatprod.3c00934. Epub 2024 Jan 22.

Caged Xanthones and Biphenyls Isolated from the Tropical Plant Garcinia lateriflora

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Caged Xanthones and Biphenyls Isolated from the Tropical Plant Garcinia lateriflora

Ayano Kobayashi et al. J Nat Prod. .

Abstract

Four cytotoxic heptacyclic caged-xanthones [gambogefic acids B-E (1-4)], a cytotoxic hexacyclic caged-xanthone [garcilatelic acid (5)], and four biphenyl derivatives [garcilatelibiphenyls A-D (6-9)] were newly isolated in a phytochemical study of a 50% MeOH/CH2Cl2 extract of Garcinia lateriflora (Clusiaceae). The isolated compounds were evaluated for antiproliferative activity against five human tumor cell lines including a vincristine-resistant line. The new caged-xanthones displayed potent activity with IC50 values from 0.5 to 6.7 μM against all tested tumor cell lines.

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