Peptide Receptor Radionuclide Therapy Using 177Lu-DOTATATE: Nursing Roles in Managing Patients With Gastroenteropancreatic Neuroendocrine Tumors

Clin J Oncol Nurs. 2024 Jan 18;28(1):79-87. doi: 10.1188/24.CJON.79-87.

Abstract

Background: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a diverse family of cancers that occur within the gastrointestinal tract and pancreas. Peptide receptor radionuclide therapy (PRRT) via 177Lu-DOTATATE is a newer therapeutic option for certain patients with somatostatin receptor-positive GEP-NETs.

Objectives: This review informs on how oncology nurses treating patients with GEP-NETs receiving PRRT using 177Lu-DOTATATE can facilitate care.

Methods: Guidance on the monitoring, management, and care of patients undergoing PRRT for GEP-NETs was developed based on published literature and the nursing experience of the authors. A case study is summarized to highlight key concepts.

Findings: Oncology nurses provide assessment, education, direct care, and emotional support when caring for patients with GEP-NETs receiving PRRT with 177Lu-DOTATATE. As the treatment landscape evolves, so too will these roles and responsibilities.

Keywords: GEP-NETs; nuclear medicine; patient management; peptide receptor radionuclide therapy.

Publication types

  • Review

MeSH terms

  • Humans
  • Intestinal Neoplasms*
  • Neuroendocrine Tumors* / radiotherapy
  • Octreotide / analogs & derivatives*
  • Organometallic Compounds*
  • Pancreatic Neoplasms*
  • Radioisotopes
  • Receptors, Peptide
  • Stomach Neoplasms*

Substances

  • lutetium Lu 177 dotatate
  • Receptors, Peptide
  • Radioisotopes
  • Organometallic Compounds
  • Octreotide

Supplementary concepts

  • Gastro-enteropancreatic neuroendocrine tumor