The inhibition of several components of terminal complement pathway results in C3 binding to PNH red blood cells

Am J Hematol. 2024 Mar;99(3):505-507. doi: 10.1002/ajh.27215. Epub 2024 Jan 24.

Abstract

C3 binding on PNH red blood cells after in vitro complement activation in normal and terminal complement depleted (∆5, ∆6, ∆9) sera: C3 binding, and the subsequent extravascular hemolysis, happens anytime there is a block of a component of the terminal complement pathway.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Complement Activation
  • Complement C3
  • Complement System Proteins / physiology
  • Erythrocytes / metabolism
  • Hemoglobinuria, Paroxysmal*
  • Hemolysis
  • Humans

Substances

  • Complement C3
  • Complement System Proteins

Grants and funding