Extended-release buprenorphine in pregnancy

Am J Addict. 2024 May;33(3):354-356. doi: 10.1111/ajad.13518. Epub 2024 Jan 24.

Abstract

Background and objectives: The relative safety and efficacy of monthly extended-release buprenorphine (XR-BUP) has not been fully evaluated in pregnant persons.

Methods: Case report of two pregnant individuals receiving XR-BUP while pregnant.

Results: Both patients had positive experiences and healthy infants.

Discussion and conclusions: Sparse data regarding the use of XR-BUP in pregnant patients limits shared decision-making. Additional evidence will support the growing population of pregnant patients exposed to XR-BUP.

Scientific significance: Positive patient experiences using XR-BUP during pregnancy have been previously unreported. This report will contribute to discussions of risks and benefits for future patients using XR-BUP during pregnancy.

Publication types

  • Case Reports

MeSH terms

  • Buprenorphine* / adverse effects
  • Delayed-Action Preparations / therapeutic use
  • Female
  • Humans
  • Naltrexone / therapeutic use
  • Narcotic Antagonists / therapeutic use
  • Opioid-Related Disorders* / drug therapy
  • Opioid-Related Disorders* / epidemiology
  • Pregnancy

Substances

  • Buprenorphine
  • Narcotic Antagonists
  • Naltrexone
  • Delayed-Action Preparations