Effective and simple interventions to improve outcomes for preterm infants worldwide: The FIGO PremPrep-5 initiative

Int J Gynaecol Obstet. 2024 Jun;165(3):929-935. doi: 10.1002/ijgo.15269. Epub 2024 Jan 24.


Preterm birth remains the leading cause of mortality among under-5's and is a major contributor to the reduction in quality-of-life adjusted years and reduction in human capital. Globally, there are many interventions and care bundles that aim to reduce the impact of preterm birth once preterm labor has ensued and into the neonatal period; not all of these are applicable in all settings. Here, we introduce the FIGO PremPrep-5 initiative, which aims to disseminate key information on the most simple and effective interventions with the aim of increasing implementation globally. Before delivery, we recommend a course of antenatal corticosteroids, and intrapartum magnesium sulfate. At delivery, we recommend delayed cord clamping. Postnatally, we recommend early feeding with breast milk and immediate kangaroo care. While there are many other interventions that may improve outcomes at the time of labor and after preterm birth, these are clinically effective and relatively inexpensive options that can be practiced in most settings and supplemented with more advanced care. We include examples of a training video and infographics that will be used for dissemination.

Keywords: antenatal steroids; breast milk; delayed cord clamping; kangaroo care; low‐ and middle‐income countries; magnesium sulfate; prematurity; preterm birth.

Publication types

  • Review
  • Video-Audio Media

MeSH terms

  • Breast Feeding
  • Delivery, Obstetric / methods
  • Female
  • Global Health
  • Humans
  • Infant, Newborn
  • Infant, Premature*
  • Kangaroo-Mother Care Method / methods
  • Magnesium Sulfate / therapeutic use
  • Pregnancy
  • Premature Birth* / prevention & control

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