RNA-binding proteins in breast cancer: Biological implications and therapeutic opportunities

Crit Rev Oncol Hematol. 2024 Mar:195:104271. doi: 10.1016/j.critrevonc.2024.104271. Epub 2024 Jan 23.

Abstract

RNA-binding proteins (RBPs) refer to a class of proteins that participate in alternative splicing, RNA stability, polyadenylation, localization and translation of RNAs, thus regulating gene expression in post-transcriptional manner. Dysregulation of RNA-RBP interaction contributes to various diseases, including cancer. In breast cancer, disorders in RBP expression and function influence the biological characteristics of tumor cells. Targeting RBPs has fostered the development of innovative therapies for breast cancer. However, the RBP-related mechanisms in breast cancer are not completely clear. In this review, we summarize the regulatory mechanisms of RBPs and their signaling crosstalk in breast cancer. Specifically, we emphasize the potential of certain RBPs as prognostic factors due to their effects on proliferation, invasion, apoptosis, and therapy resistance of breast cancer cells. Most importantly, we present a comprehensive overview of the latest RBP-related therapeutic strategies and novel therapeutic targets that have proven to be useful in the treatment of breast cancer.

Keywords: Breast cancer; RNA; RNA-binding protein; Therapeutic targets.

Publication types

  • Review

MeSH terms

  • Breast Neoplasms* / genetics
  • Breast Neoplasms* / therapy
  • Female
  • Humans
  • RNA-Binding Proteins / genetics

Substances

  • RNA-Binding Proteins