Antibacterial p-terphenyl and α‑pyrone derivates isolated from the marine-derived actinomycete Nocardiopsis sp. HDN154086

Luning Zhou; Yimin Chang; Shengkuan Yang; Xiaofei Huang; Jiaxiang Wang; Chengyu Jiang; Tianjiao Zhu; Dehai Li; Qian Che

doi:10.1038/s41429-023-00698-9

Antibacterial p-terphenyl and α‑pyrone derivates isolated from the marine-derived actinomycete Nocardiopsis sp. HDN154086

J Antibiot (Tokyo). 2024 Apr;77(4):201-205. doi: 10.1038/s41429-023-00698-9. Epub 2024 Jan 25.

Authors

Luning Zhou^#¹, Yimin Chang^#¹, Shengkuan Yang¹, Xiaofei Huang¹, Jiaxiang Wang¹, Chengyu Jiang², Tianjiao Zhu^{1

3}, Dehai Li^{4

5}, Qian Che^{6

7}

Affiliations

¹ Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, PR China.
² Marine Biomedical Research Institute of Qingdao, Qingdao, 266237, PR China.
³ Laboratory for Marine Drugs and Bioproducts of Qingdao Pilot National Laboratory for Marine Science and Technology, Qingdao, 266237, PR China.
⁴ Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, PR China. dehaili@ouc.edu.cn.
⁵ Laboratory for Marine Drugs and Bioproducts of Qingdao Pilot National Laboratory for Marine Science and Technology, Qingdao, 266237, PR China. dehaili@ouc.edu.cn.
⁶ Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, PR China. cheqian064@ouc.edu.cn.
⁷ Laboratory for Marine Drugs and Bioproducts of Qingdao Pilot National Laboratory for Marine Science and Technology, Qingdao, 266237, PR China. cheqian064@ouc.edu.cn.

^# Contributed equally.

PMID: 38273126
DOI: 10.1038/s41429-023-00698-9

Abstract

Assisted by OSMAC strategy, one new p-terphenyl and two new α‑pyrone derivates, namely nocarterphenyl I (1) and nocardiopyrone D-E (2-3), were obtained and characterized from the marine sediment-derived actinomycete Nocardiopsis sp. HDN154086. The structures of these compounds were determined on the basis of MS, NMR spectroscopic data and single-crystal X-ray diffraction. Compound 1 with a rare 2,2'-bithiazole structure among natural products showed promising activity against five bacteria with MIC values ranging from 0.8 to 1.6 μM and 3 exhibited notable antibacterial activity against MRSA compared the positive control ciprofloxacin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Actinobacteria* / chemistry
Anti-Bacterial Agents / chemistry
Molecular Structure
Nocardiopsis
Pyrones / chemistry
Terphenyl Compounds* / chemistry

Substances

Pyrones
Anti-Bacterial Agents
Terphenyl Compounds