Meningeal Solitary Fibrous Tumor: A Single-Center Retrospective Cohort Study

Siyer Roohani; Yasemin Alberti; Maximilian Mirwald; Felix Ehret; Carmen Stromberger; Soleiman Fabris Roohani; Katja Bender; Anne Flörcken; Sven Märdian; Daniel Zips; David Kaul

doi:10.1155/2024/8846018

Meningeal Solitary Fibrous Tumor: A Single-Center Retrospective Cohort Study

Sarcoma. 2024 Jan 17:2024:8846018. doi: 10.1155/2024/8846018. eCollection 2024.

Authors

Siyer Roohani^{1

2

3}, Yasemin Alberti⁴, Maximilian Mirwald¹, Felix Ehret^{1

3}, Carmen Stromberger⁵, Soleiman Fabris Roohani¹, Katja Bender¹, Anne Flörcken^{3

6}, Sven Märdian⁷, Daniel Zips^{1

3}, David Kaul^{1

3}

Affiliations

¹ Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Radiation Oncology, Augustenburger Platz 1, Berlin 13353, Germany.
² Berlin Institute of Health at Charité-Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charité Junior Clinician Scientist Program, Charitéplatz 1, Berlin 10117, Germany.
³ Charité-Universitätsmedizin Berlin, German Cancer Consortium (DKTK), Partner Site Berlin, and German Cancer Research Center (DKFZ), Berlin, Germany.
⁴ Department of Radiotherapy, West German Cancer Center, University of Duisburg-Essen, University Hospital Essen, Essen, Germany.
⁵ Vivantes Klinikum Neukölln, Department of Radiooncology and Radiotherapy, Berlin, Germany.
⁶ Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Hematology, Oncology and Tumor Immunology, Augustenburger Platz 1, Berlin 13353, Germany.
⁷ Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Campus Virchow-Klinikum, Augustenburger Platz 1, Berlin 13353, Germany.

Abstract

Background: Meningeal solitary fibrous tumors (SFTs) are rare, malignant, mesenchymal tumors of the central nervous system. While surgical gross total resection is widely accepted as a positive prognostic factor for local control (LC), the role of postoperative radiotherapy (PORT) remains controversial. We sought to report our institutional experience with a particular focus on outcomes after PORT.

Materials and methods: In this single-center, retrospective cohort study, 20 patients with the primary diagnosis of histopathologically confirmed meningeal SFT were analyzed. Data on patient characteristics, imaging, treatment modalities, histopathology, and oncological outcomes were collected. LC and overall survival (OS) were assessed using the Kaplan-Meier estimator.

Results: The median follow-up time was 95.8 months. After surgery only, 9 out of 11 patients (81.8%) developed a local recurrence while, after surgery and PORT, 3 out of 9 patients (33.33%) showed local failure. The 5- and 10-year LC rates were 50.5% and 40.4% in the surgery-only group and 80% at both time points in the surgery with the PORT group. In the surgery-only group, 4 out of 11 patients (36.4%) died, and 4 out of 9 patients (44.4%) died in the surgery and PORT group. OS rates after 5 and 10 years were 88.9% and 66.7% in the surgery-only group and 88.9% and 76.2% in the surgery with PORT group.

Conclusions: Our findings suggest that PORT may improve LC in patients with meningeal SFT. The low incidence of meningeal SFT impedes prospective studies and requires further international collaborative efforts to exploit retrospective datasets and molecular analysis to improve patient outcomes.