Emerging therapeutic approaches of SHP2-targeted modulators

Xinyu Yang; Jinbo Xiong; Bin Yu; Yihui Song

doi:10.4155/fmc-2023-0348

Emerging therapeutic approaches of SHP2-targeted modulators

Future Med Chem. 2024 Feb;16(4):291-294. doi: 10.4155/fmc-2023-0348. Epub 2024 Jan 26.

Authors

Xinyu Yang¹, Jinbo Xiong¹, Bin Yu^{2

3}, Yihui Song¹

Affiliations

¹ School of Pharmaceutical Sciences & Key Laboratory of Advanced Drug Preparation Technologies, Zhengzhou University, Zhengzhou, 450001, China.
² College of Chemistry, Pingyuan Laboratory, Zhengzhou University, Zhengzhou, 450001, China.
³ Tianjian Laboratory of Advanced Biomedical Sciences, Institute of Advanced Biomedical Sciences, Zhengzhou University, Zhengzhou, 450000, China.

PMID: 38275153
DOI: 10.4155/fmc-2023-0348

Abstract

Tweetable abstract Monotherapy and combination therapy of SHP2 regulator for cancer treatment.

Keywords: SHP2 modulator; combination therapy; epigenetic inhibitors; immune checkpoint blockers; kinase inhibitors; protein tyrosine phosphatases.

Publication types

Editorial
Research Support, Non-U.S. Gov't

MeSH terms

Protein Tyrosine Phosphatase, Non-Receptor Type 11*

Substances

Protein Tyrosine Phosphatase, Non-Receptor Type 11

Grants and funding

32371317/National Natural Science Foundation of China