Myxoinflammatory Fibroblastic Sarcoma

Hao Wu; William B Laskin

doi:10.1016/j.path.2023.07.003

Myxoinflammatory Fibroblastic Sarcoma

Surg Pathol Clin. 2024 Mar;17(1):83-96. doi: 10.1016/j.path.2023.07.003. Epub 2023 Aug 8.

Authors

Hao Wu¹, William B Laskin²

Affiliations

¹ Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA.
² Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: william.laskin@yale.edu.

PMID: 38278610
DOI: 10.1016/j.path.2023.07.003

Abstract

MIFS is a low-grade fibroblastic sarcoma that predilects to superficial distal extremity soft tissue. It is composed of plump spindled and epithelioid cells, inflammatory infiltrates, and mucin deposits in a fibrosclerotic stroma. Large epithelioid cells harboring bizarre nuclei and virocyte-like macronucleoli and pleomorphic pseudolipoblasts are characteristic. While conventional MIFS has locally recurrent potential but minimal metastatic risk, tumors with high-grade histologic features have a greater risk for recurrence and metastasis. Wide local excision is the recommended treatment.

Keywords: Emperipolesis; Myxoinflammatory fibroblastic sarcoma; Pseudolipoblasts; Reed-Sternberg-like cells; Virocyte-like cells.

Publication types

Review

MeSH terms

Fibroblasts / pathology
Fibrosarcoma* / diagnosis
Fibrosarcoma* / pathology
Fibrosarcoma* / surgery
Humans
Sarcoma* / diagnosis
Sarcoma* / pathology
Skin Neoplasms* / pathology
Soft Tissue Neoplasms* / diagnosis
Soft Tissue Neoplasms* / pathology