Cell attachment and chemotaxis can utilize the same peptide sequence of fibronectin

Biochim Biophys Acta. 1987 Apr 2;928(1):114-8. doi: 10.1016/0167-4889(87)90092-9.

Abstract

Fibronectin and fragments of the parent molecule are involved in cell-substrate attachment, cell migration and chemotaxis. The cell attachment sequence, Gly-Arg-Gly-Asp-Ser-Pro, was synthesized and tested for its ability to effect ligamentum nuchae fibroblast chemotaxis. This hexapeptide and fibronectin itself both caused directed cell migration, with maximal activity in the 10(-10) to 10(-9) M range. These data demonstrate that the fibronectin cell binding site and chemotaxis site share a common sequence.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cattle
  • Cell Adhesion*
  • Cells, Cultured
  • Chemotaxis*
  • Fibronectins / physiology*
  • Ligaments / cytology
  • Oligopeptides / pharmacology
  • Structure-Activity Relationship

Substances

  • Fibronectins
  • Oligopeptides