[Effect of cobalamin derivatives on DNA synthesis in cells of Propionibacterium freudenreichii subsp. shermanii]

Nauchnye Doki Vyss Shkoly Biol Nauki. 1987;(1):5-10.
[Article in Russian]


The increase of DNA-synthesis rate (according incorporation [8-14C]adenine) in B12-deficient cells Propionibacterium shermanii as a result of different cobalamines adding into the cell suspension including metoxyethyladenile analog of adenozilcobalamin and some components of vitamin B12 molecule has been found. The DNA-synthesis rate in B12-deficient cells is nearly twice lower as compared with one in B12-normal cells. Considerable stimulative effect (80-100%) was provided with coenzyme forms of cobalamin. The data confirm the participation of vitamin B12 in DNA-synthesis in Propionibacterium cells.

Publication types

  • English Abstract

MeSH terms

  • DNA, Bacterial / biosynthesis*
  • DNA, Bacterial / drug effects
  • Hydroxyurea / pharmacology
  • Propionibacterium / drug effects
  • Propionibacterium / metabolism*
  • Vitamin B 12 / analogs & derivatives
  • Vitamin B 12 / pharmacology*


  • DNA, Bacterial
  • Vitamin B 12
  • Hydroxyurea