Effects of beta-endorphin2-9 on arginine-8-vasopressin and oxytocin levels in hypothalamic and limbic brain regions

Brain Res. 1987 Feb 10;403(1):155-7. doi: 10.1016/0006-8993(87)90136-3.

Abstract

Immunoreactive arginine-8-vasopressin (AVP) and oxytocin (OXT) were measured in rat hypothalamic and limbic brain regions after the intracerebroventricular administration of beta-endorphin fragment 2-9 (beta E2-9). The peptide decreased the AVP content of the hippocampus and the OXT levels in the septum and amygdala. The present data favor the view that beta E2-9 interacts with limbic AVP- and OXT-systems.

MeSH terms

  • Amygdala / drug effects
  • Amygdala / metabolism
  • Animals
  • Arginine Vasopressin / metabolism*
  • Endorphins / pharmacology*
  • Hippocampus / drug effects
  • Hippocampus / metabolism
  • Hypothalamus / drug effects
  • Hypothalamus / metabolism*
  • Limbic System / drug effects
  • Limbic System / metabolism*
  • Male
  • Oxytocin / metabolism*
  • Peptide Fragments / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Septum Pellucidum / drug effects
  • Septum Pellucidum / metabolism
  • beta-Endorphin*

Substances

  • Endorphins
  • Peptide Fragments
  • Arginine Vasopressin
  • Oxytocin
  • beta-Endorphin
  • beta-endorphin (2-9)