Lion’s mane, Hericium erinaceus, is an edible mushroom found most abundantly in East Asia that has been used widely as a food and as an herbal medication in traditional Chinese medicine. Recently, lion’s mane has been purported to improve cognition and relieve anxiety and depression. Lion’s mane is generally recognized as safe and has not been linked to serum enzyme elevations during therapy nor to episodes of clinically apparent liver injury.