Glymphatic-stagnated edema induced by traumatic brain injury

Trends Pharmacol Sci. 2024 Jan 29:S0165-6147(24)00018-X. doi: 10.1016/j.tips.2024.01.005. Online ahead of print.

Abstract

Traumatic brain injury (TBI) outcomes are notably affected by brain edema. A recent report by Hussain et al. unveils a unique form, glymphatic-stagnated brain edema, that stems from impaired glymphatic and lymphatic drainage induced by noradrenergic activation. Consequently, pan-noradrenergic inhibition may emerge as an innovative treatment for TBI-related edema, challenging traditional therapeutic approaches.

Keywords: brain edema; glymphatic; meningeal lymphatic; outcome; traumatic brain injury.