Maternal obesity induced metabolic disorders in offspring and myeloid reprogramming by epigenetic regulation

Joo Young Kweon; Hyeonji Mun; Myeong Ryeol Choi; Hong Seok Kim; Yong Joo Ahn

doi:10.3389/fendo.2023.1256075

Maternal obesity induced metabolic disorders in offspring and myeloid reprogramming by epigenetic regulation

Front Endocrinol (Lausanne). 2024 Jan 16:14:1256075. doi: 10.3389/fendo.2023.1256075. eCollection 2023.

Authors

Joo Young Kweon^#¹, Hyeonji Mun^#¹, Myeong Ryeol Choi^#¹, Hong Seok Kim², Yong Joo Ahn^{1

3}

Affiliations

¹ Medical Science and Engineering, Graduate School of Convergence Science and Technology, Pohang University of Science and Technology, Pohang, Republic of Korea.
² Department of Molecular Medicine, College of Medicine, Inha University, Incheon, Republic of Korea.
³ Department IT Convergence, Pohang University of Science and Technology, Pohang, Republic of Korea.

^# Contributed equally.

Abstract

Maternal obesity and gestational diabetes are associated with childhood obesity and increased cardiovascular risk. In this review, we will discuss and summarize extensive clinical and experimental studies that metabolically imbalanced environment exposure in early life plays a critical role in influencing later susceptibility to chronic inflammatory diseases and metabolic syndrome. The effect of maternal obesity and metabolic disorders, including gestational diabetes cause Large-for-gestational-age (LGA) children to link future development of adverse health issues such as obesity, atherosclerosis, hypertension, and non-alcoholic fatty liver disease by immune reprogramming to adverse micro-environment. This review also addresses intrauterine environment-driven myeloid reprogramming by epigenetic regulations and the epigenetic markers as an underlying mechanism. This will facilitate future investigations regarding maternal-to-fetal immune regulation and the epigenetic mechanisms of obesity and cardiovascular diseases.

Keywords: diabetes; epigenetic regulation; fetal development; maternal obesity; reprogramming.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Child
Diabetes, Gestational* / genetics
Epigenesis, Genetic
Female
Humans
Metabolic Syndrome* / genetics
Obesity, Maternal*
Pediatric Obesity*
Pregnancy

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Research Foundation (NRF) grant funded by Korea government (MSIT) (No. RS-2023-00243134).