A familial occurrence of allergic bronchopulmonary aspergillosis

Ann Intern Med. 1979 Sep;91(3):378-82. doi: 10.7326/0003-4819-91-3-378.


A family was recently studied in which two brothers with identical HLA serotypes had allergic bronchopulmonary aspergillosis. One of the two had a normal bronchogram. A field investigation of the family residence showed that a barn was the probable source of the organism causing disease in these patients. Immunologic characterization of the family members showed a broad spectrum of response to the environmental exposure.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aspergillosis, Allergic Bronchopulmonary / diagnostic imaging
  • Aspergillosis, Allergic Bronchopulmonary / genetics*
  • Aspergillosis, Allergic Bronchopulmonary / immunology
  • Asthma / complications
  • Bronchography
  • Child
  • Child, Preschool
  • Conjunctivitis / complications
  • Disease Reservoirs
  • Female
  • HLA Antigens / analysis
  • Humans
  • Immunologic Techniques
  • Infant
  • Infant, Newborn
  • Male
  • Middle Aged
  • Rhinitis / complications
  • Skin Tests


  • HLA Antigens