Mitomycin intravascular chemoembolization (MICE) to treat corneal vascularization prior to penetrating keratoplasty

Neal Rangu; Kamran M Riaz

doi:10.1016/j.ajoc.2024.101993

Mitomycin intravascular chemoembolization (MICE) to treat corneal vascularization prior to penetrating keratoplasty

Am J Ophthalmol Case Rep. 2024 Jan 14:33:101993. doi: 10.1016/j.ajoc.2024.101993. eCollection 2024 Mar.

Authors

Neal Rangu^{1

2}, Kamran M Riaz^{1

2}

Affiliations

¹ Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
² College of Medicine, University of Oklahoma, Oklahoma City, OK, USA.

Abstract

Purpose: To present the clinical outcome of mitomycin intravascular chemoembolization (MICE) as a prophylactic treatment in a patient with HSV-induced corneal neovascularization (NV) before penetrating keratoplasty (PKP).

Observations: A 53-year-old male patient presented with a medical history of recurrent herpes simplex virus (HSV) corneal infection. The patient reported worsening visual acuity despite maintenance treatment with systemic antivirals and topical corticosteroids. After the appearance of corneal NV, subconjunctival triamcinolone and bevacizumab injections were given with limited and temporary improvement. Due to worsening corneal NV, MICE was subsequently performed, resulting in the elimination of corneal NV from the visual axis, which allowed for successful PKP 4 months later. Cataract surgery was performed 6 months after PKP.

Conclusions and importance: This report describes the potential efficacy of MICE as a prophylactic treatment for corneal NV prior to PKP.

Keywords: Corneal neovascularization; Mitomycin intravascular chemoembolization; Penetrating keratoplasty.

Publication types

Case Reports