Comparative prevalence of gallstone disease at 100-year interval in a large Romanian town, a necropsy study

Dig Dis Sci. 1987 Apr;32(4):354-7. doi: 10.1007/BF01296287.


The prevalence of gallstone disease in a large Romanian town was determined on 6275 necropsies performed during a 10-year period (1973-1982). The "crude" prevalence of gallstone disease in women was 17.1% and in men, 6.9%. Age-standardized prevalence was 8.4% in women and 5.0% in men. This rate is lower than the prevalence of gallstones in northern or central European countries, but it is higher than that established in some southern countries of Europe. A comparison of the "crude" prevalence of gallstone disease was compared with that calculated for a similar 10-year period 100 years ago (1873-1882), on 1538 necropsies performed in the same town. Prevalence of gallstones rose significantly in a century (from a mean of 1.2% to 11.3%; P less than 0.001), a finding consistent with the concept that gallstone disease is a "disease of civilization."

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Autopsy
  • Cholecystectomy
  • Cholelithiasis / epidemiology*
  • Cholelithiasis / history
  • Female
  • Humans
  • Male
  • Middle Aged
  • Romania
  • Sex Factors