Bisphenol chemicals in colostrum from Shanghai, China during 2006-2019: Concentration, temporal variation, and potential influence on birth parameters

Xiaolan Zhang; Minghui Fu; Kexin Li; Xiaomeng Cheng; Xinyu Zhang; Xiuhua Shen; Bingli Lei; Yingxin Yu

doi:10.1016/j.fct.2024.114485

Bisphenol chemicals in colostrum from Shanghai, China during 2006-2019: Concentration, temporal variation, and potential influence on birth parameters

Food Chem Toxicol. 2024 Mar:185:114485. doi: 10.1016/j.fct.2024.114485. Epub 2024 Feb 1.

Authors

Xiaolan Zhang¹, Minghui Fu², Kexin Li², Xiaomeng Cheng³, Xinyu Zhang⁴, Xiuhua Shen⁵, Bingli Lei⁶, Yingxin Yu⁷

Affiliations

¹ School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China; Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou, 510006, P. R. China.
² School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.
³ School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China; School of Public Health, Hongqiao International Institute of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
⁴ School of Public Health, Hongqiao International Institute of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
⁵ Department of Clinical Nutrition, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Department of Clinical Nutrition, College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
⁶ School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China. Electronic address: leibingli@shu.edu.cn.
⁷ Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou, 510006, P. R. China. Electronic address: yuyingxin@gdut.edu.cn.

PMID: 38301991
DOI: 10.1016/j.fct.2024.114485

Abstract

Bisphenol A (BPA) and its alternatives bisphenol S (BPS) and bisphenol F (BPF) are identified as endocrine disruptors that have negative impacts on infant growth. Their temporal variations in human milk and potential effects on fetal growth are not well known. In this study, colostrum collecting at four time points between 2006 and 2019 and paired urine in 2019 from Shanghai, China, were analyzed for eight bisphenols. The total concentrations in colostrum in 2019 were up to 3.43 ng/mL, with BPA being dominant, followed by BPS and BPF. BPA levels in colostrum noticeably decreased from 2010 to 2013. Additionally, obvious percentage changes in bisphenols were observed in 2019. The BPA concentrations in paired colostrum and urine were not significantly correlated. High levels of BPA in colostrum were linked to a significant reduction in birth head circumference in 2019 (p = 0.031). BPA and BPS in colostrum might have similar negative effect on fetal growth in 2019, but these effects were generally non-significant. Further studies are needed to testify the potential impact. The hazard indexes for infants in the first week of life were below 1, suggesting no obvious health risks. However, the high contribution from BPA still warrants further attention.

Keywords: Bisphenols; Colostrum; Health risk assessment; Prenatal exposure; Temporal variation.

MeSH terms

Benzhydryl Compounds / toxicity
China
Colostrum*
Female
Fetal Development*
Humans
Phenols*
Pregnancy

Substances

bisphenol A
bisphenol F
Benzhydryl Compounds
Phenols