The influence of inosine on adriamycin-induced cardiomyopathy in rats

Eur J Cancer Clin Oncol. 1986 Nov;22(11):1357-63. doi: 10.1016/0277-5379(86)90145-8.

Abstract

The effect of inosine on adriamycin-induced cardiomyopathy was studied. Total adriamycin (ADR) dose of 25 mg/kg i.p. injected in 15 equal partial doses 3 times a week for five following weeks evoked fully developed cardiomyopathy in rats. Inosine 200 mg/kg i.p. injected 5 times a week parallel to ADR diminished ADR cardiotoxicity evaluated by electrocardiographic recordings and histopathological examination. Moreover lower cytostatic toxicity was observed as judged by less-expressed leucopenia and lower SGOT activities in inosine treated animals.

MeSH terms

  • Animals
  • Cardiomyopathies / chemically induced
  • Cardiomyopathies / pathology
  • Cardiomyopathies / prevention & control*
  • Doxorubicin / toxicity*
  • Electrocardiography
  • Inosine / therapeutic use*
  • Male
  • Myocardium / pathology
  • Rats
  • Rats, Inbred Strains
  • Time Factors

Substances

  • Inosine
  • Doxorubicin