A proton birdcage coil integrated with interchangeable single loops for multi-nuclear MRI/MRS
J Zhejiang Univ Sci B. 2024 Feb 15;25(2):168-180.
doi: 10.1631/jzus.B2300587.
[Article in
English,
Chinese]
Affiliations
- 1 Department of Neurosurgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
- 2 Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou 310009, China.
- 3 MOE Frontier Science Center for Brain Science and Brain-machine Integration, Zhejiang University, Hangzhou 310058, China.
- 4 Interdisciplinary Institute of Neuroscience and Technology, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310027, China.
- 5 School of Medicine, Zhejiang University, Hangzhou 310020, China.
- 6 iHuman Institute, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
- 7 Department of Neurosurgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China. d-chengao@zju.edu.cn.
- 8 Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou 310009, China. d-chengao@zju.edu.cn.
- 9 Department of Neurosurgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China. d-chengao@zju.edu.cn, zhangxiaotong@zju.edu.cn.
- 10 Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou 310009, China. d-chengao@zju.edu.cn, zhangxiaotong@zju.edu.cn.
- 11 MOE Frontier Science Center for Brain Science and Brain-machine Integration, Zhejiang University, Hangzhou 310058, China. d-chengao@zju.edu.cn, zhangxiaotong@zju.edu.cn.
- 12 Interdisciplinary Institute of Neuroscience and Technology, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310027, China. d-chengao@zju.edu.cn, zhangxiaotong@zju.edu.cn.
- 13 School of Medicine, Zhejiang University, Hangzhou 310020, China. d-chengao@zju.edu.cn, zhangxiaotong@zju.edu.cn.
- 14 College of Electrical Engineering, Zhejiang University, Hangzhou 310027, China. d-chengao@zju.edu.cn, zhangxiaotong@zju.edu.cn.
Energy metabolism is fundamental for life. It encompasses the utilization of carbohydrates, lipids, and proteins for internal processes, while aberrant energy metabolism is implicated in many diseases. In the present study, using three-dimensional (3D) printing from polycarbonate via fused deposition modeling, we propose a multi-nuclear radiofrequency (RF) coil design with integrated 1H birdcage and interchangeable X-nuclei (2H, 13C, 23Na, and 31P) single-loop coils for magnetic resonance imaging (MRI)/magnetic resonance spectroscopy (MRS). The single-loop coil for each nucleus attaches to an arc bracket that slides unrestrictedly along the birdcage coil inner surface, enabling convenient switching among various nuclei and animal handling. Compared to a commercial 1H birdcage coil, the proposed 1H birdcage coil exhibited superior signal-excitation homogeneity and imaging signal-to-noise ratio (SNR). For X-nuclei study, prominent peaks in spectroscopy for phantom solutions showed excellent SNR, and the static and dynamic peaks of in vivo spectroscopy validated the efficacy of the coil design in structural imaging and energy metabolism detection simultaneously.
能量代谢对生命活动至关重要，主要包括对碳水化合物、脂肪和蛋白质的利用过程，异常的能量代谢与诸多疾病密切相关。本研究提出了一种用于多核磁共振成像（MRI）与波谱（MRS）的射频线圈设计：通过3D打印线圈外壳和支架，将一个鸟笼1H线圈和可更换的单环X核（2H、13C、23Na和31P）线圈一体化集成，其中单环线圈通过一个弧形支架安装于鸟笼线圈内壁，使其可沿内壁轴向无阻碍地移动，方便实现成像实验中多核线圈的更换以及线圈相对于不同成像体的摆放。与商用鸟笼1H核线圈相比，本设计具有更好的1H信号激发均匀性和成像信噪比；小鼠的活体实验验证了线圈设计在成像与波谱研究方面的可行性与有效性，可同时满足结构成像和能量代谢检测的要求。综上所述，该多核线圈通过新型机械与电路设计可以简化多核磁共振成像能量代谢检测的实施过程。.
能量代谢对生命活动至关重要，主要包括对碳水化合物、脂肪和蛋白质的利用过程，异常的能量代谢与诸多疾病密切相关。本研究提出了一种用于多核磁共振成像（MRI）与波谱（MRS）的射频线圈设计：通过3D打印线圈外壳和支架，将一个鸟笼 1H线圈和可更换的单环X核（ 2H、 13C、 23Na和 31P）线圈一体化集成，其中单环线圈通过一个弧形支架安装于鸟笼线圈内壁，使其可沿内壁轴向无阻碍地移动，方便实现成像实验中多核线圈的更换以及线圈相对于不同成像体的摆放。与商用鸟笼 1H核线圈相比，本设计具有更好的 1H信号激发均匀性和成像信噪比；小鼠的活体实验验证了线圈设计在成像与波谱研究方面的可行性与有效性，可同时满足结构成像和能量代谢检测的要求。综上所述，该多核线圈通过新型机械与电路设计可以简化多核磁共振成像能量代谢检测的实施过程。
Keywords:
Energy metabolism; Magnetic resonance imaging (MRI); Magnetic resonance spectroscopy (MRS); Multi-nuclear; Radiofrequency coil; Three-dimensional (3D) printing.
MeSH terms
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Animals
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Equipment Design
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Magnetic Resonance Imaging* / methods
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Magnetic Resonance Spectroscopy
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Phantoms, Imaging
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Protons*
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Signal-To-Noise Ratio