Parathyroid hormone-like bioactivity in tumours from patients with oncogenic osteomalacia

Clin Endocrinol (Oxf). 1985 Dec;23(6):689-97. doi: 10.1111/j.1365-2265.1985.tb01130.x.

Abstract

Extracts from the tumours of three patients with oncogenic osteomalacia stimulated renal adenylate cyclase in a parathyroid hormone (PTH) responsive system. The stimulation was suppressed by a specific PTH antagonist. These observations suggest that osteomalacia-producing tumours exert some of their effects through PTH-like material acting on PTH receptors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenylyl Cyclases / metabolism
  • Adolescent
  • Adult
  • Aged
  • Animals
  • Biological Assay
  • Bone Neoplasms / metabolism*
  • Chickens
  • Female
  • Humans
  • In Vitro Techniques
  • Kidney / enzymology
  • Male
  • Osteomalacia / metabolism*
  • Parathyroid Hormone / metabolism*
  • Syndrome
  • Tissue Extracts / pharmacology

Substances

  • Parathyroid Hormone
  • Tissue Extracts
  • Adenylyl Cyclases