Abstract
Extracts from the tumours of three patients with oncogenic osteomalacia stimulated renal adenylate cyclase in a parathyroid hormone (PTH) responsive system. The stimulation was suppressed by a specific PTH antagonist. These observations suggest that osteomalacia-producing tumours exert some of their effects through PTH-like material acting on PTH receptors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenylyl Cyclases / metabolism
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Adolescent
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Adult
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Aged
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Animals
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Biological Assay
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Bone Neoplasms / metabolism*
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Chickens
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Female
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Humans
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In Vitro Techniques
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Kidney / enzymology
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Male
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Osteomalacia / metabolism*
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Parathyroid Hormone / metabolism*
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Syndrome
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Tissue Extracts / pharmacology
Substances
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Parathyroid Hormone
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Tissue Extracts
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Adenylyl Cyclases