Regulated cell death in glioma: promising targets for natural small-molecule compounds

Mingyu Han; Sui Li; Huali Fan; Junsha An; Cheng Peng; Fu Peng

doi:10.3389/fonc.2024.1273841

Regulated cell death in glioma: promising targets for natural small-molecule compounds

Front Oncol. 2024 Jan 18:14:1273841. doi: 10.3389/fonc.2024.1273841. eCollection 2024.

Authors

Mingyu Han¹, Sui Li¹, Huali Fan¹, Junsha An¹, Cheng Peng², Fu Peng^{1

3}

Affiliations

¹ West China School of Pharmacy, Sichuan University, Chengdu, China.
² State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
³ Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Sichuan University, Chengdu, China.

Abstract

Gliomas are prevalent malignant tumors in adults, which can be categorized as either localized or diffuse gliomas. Glioblastoma is the most aggressive and deadliest form of glioma. Currently, there is no complete cure, and the median survival time is less than one year. The main mechanism of regulated cell death involves organisms coordinating the elimination of damaged cells at risk of tumor transformation or cells hijacked by microorganisms for pathogen replication. This process includes apoptosis, necroptosis, autophagy, ferroptosis, pyroptosis, necrosis, parthanayosis, entosis, lysosome-dependent death, NETosis, oxiptosis, alkaliptosis, and disulfidaptosis. The main goal of clinical oncology is to develop therapies that promote the effective elimination of cancer cells by regulating cell death are the main goal of clinical oncology. Recently, scientists have utilized pertinent regulatory factors and natural small-molecule compounds to induce regulated cell death for the treatment of gliomas. By analyzing the PubMed and Web of Science databases, this paper reviews the research progress on the regulation of cell death and the role of natural small-molecule compounds in glioma. The aim is to provide help for the treatment of glioblastoma.

Keywords: glioma; natural small-molecule compounds; pathways; regulated cell death; regulatory factors.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The study was supported by National Natural Science Foundation of China (no.82003879 and U19A2010). Project of Science and Technology Department of Sichuan Province (no. 2021YFS0044), National Natural Science Foundation of Science and Technology Department of Sichuan Province (no.2023NSFSC1928), the Project of State Administration of Traditional Chinese Medicine of China (no. ZYYCXTD-D-202209), Young Elite Scientists Sponsorship Programby China Association for Science and Technology (no. CACM-2020-QNRC1-01), the Open Research Fund of State Key Laboratory of Southwestern Chinese Medicine Resources (no.SKLTCM202205), and the Fundamental Research Funds for the central Universities.