Al18F-NOTA-Octreotide PET/CT and 18F-FDG PET/CT for Detecting Cerebellar Hemangioblastoma in a Patient With Von Hippel-Lindau Disease

Clin Nucl Med. 2024 Mar 1;49(3):289-291. doi: 10.1097/RLU.0000000000005042.

Abstract

Von Hippel-Lindau disease is a hereditary syndrome associated with various benign and malignant tumors, including hemangioblastomas. A 42-year-old man with a history of Von Hippel-Lindau disease underwent surgery for pancreatic neuroendocrine tumor and renal clear cell carcinoma and was recommended to undergo Al18F-NOTA-octreotide and 18F-FDG PETCT examination to assess potential metastases. 18F-FDG PET/CT showed low uptake in the right cerebellum, which demonstrated increased Al18F-NOTA-octreotide activity. Cerebellar mass resection surgery was performed. Pathological result was consistent with hemangioblastoma. This case report indicates the significant role of Al18F-NOTA-octreotide in the diagnosis of hemangioblastoma.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cerebellar Neoplasms* / complications
  • Cerebellar Neoplasms* / diagnostic imaging
  • Fluorine Radioisotopes*
  • Fluorodeoxyglucose F18
  • Hemangioblastoma* / complications
  • Hemangioblastoma* / diagnostic imaging
  • Humans
  • Kidney Neoplasms* / pathology
  • Male
  • Octreotide / analogs & derivatives*
  • Organometallic Compounds*
  • Positron Emission Tomography Computed Tomography
  • von Hippel-Lindau Disease* / complications
  • von Hippel-Lindau Disease* / diagnostic imaging

Substances

  • Fluorodeoxyglucose F18
  • Al18F-NOTA-octreotide
  • Fluorine Radioisotopes
  • Organometallic Compounds
  • Octreotide