Structure is beauty, but not always truth

Cell. 2024 Feb 1;187(3):517-520. doi: 10.1016/j.cell.2024.01.003.

Abstract

Structural biology, as powerful as it is, can be misleading. We highlight four fundamental challenges: interpreting raw experimental data; accounting for motion; addressing the misleading nature of in vitro structures; and unraveling interactions between drugs and "anti-targets." Overcoming these challenges will amplify the impact of structural biology on drug discovery.

MeSH terms

  • Beauty
  • Drug Discovery*
  • Molecular Biology*