Abstract
In a recent study in Cell, Malachowski et al.1 show that the trinucleotide expansion in the FMR1 gene underlying fragile X syndrome triggers formation of large heterochromatin domains across the genome, resulting in the repression of synaptic genes housed within these domains.
Copyright © 2024 Elsevier Inc. All rights reserved.
MeSH terms
-
Fragile X Mental Retardation Protein / genetics
-
Fragile X Mental Retardation Protein / metabolism
-
Fragile X Syndrome* / genetics
-
Heterochromatin / genetics
-
Humans
-
Promoter Regions, Genetic
-
Trinucleotide Repeat Expansion / genetics
-
Trinucleotide Repeats / genetics
Substances
-
Heterochromatin
-
Fragile X Mental Retardation Protein
-
FMR1 protein, human