A comparative study of the HI test and paper spot test for screening dapsone in urine was carried out in 692 specimens of urine, 149 from the field and 502 from patients attending the C.L.T. and R.I. clinic or admitted in the wards and 41 control urines. A very good correlation was noticed between the 2 tests in relation to positivity or negativity as well as DDS concentration. Fifty one urine specimens showed a specific agglutination, 41 of them were considered HI positive and 10 of them HI negative based on DDS concentration. The results are discussed.