[Multiple myeloma with myelofibrosis at diagnosis and aggressive extramedullary relapse after autologous stem cell transplantation]

Rinsho Ketsueki. 2024;65(1):1-6. doi: 10.11406/rinketsu.65.1.
[Article in Japanese]


A 66-year-old man was diagnosed with symptomatic IgG-λ multiple myeloma based on the presence of anemia, thrombocytopenia, renal dysfunction, and a tumor on the right sixth rib. Bone marrow aspiration yielded a dry tap and biopsy revealed myelofibrosis grade 2. Partial response was achieved with Bd (bortezomib and dexamethasone) and VRd (bortezomib, lenalidomide, and dexamethasone). The patient received autologous stem cell transplantation, but the myeloma relapsed 3 months later, and liver tumors developed as well. DKd (daratumumab, carfilzomib, and dexamethasone) was administered, but the patient died due to disease progression. Autopsy revealed multiple extramedullary lesions in the liver, spleen, gallbladder, adrenal glands, kidneys, and multiple lymph nodes, as well as ascites.

Keywords: Extramedullary lesion; Multiple myeloma; Myelofibrosis.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bortezomib / therapeutic use
  • Dexamethasone / therapeutic use
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Male
  • Multiple Myeloma* / complications
  • Multiple Myeloma* / diagnosis
  • Multiple Myeloma* / therapy
  • Neoplasm Recurrence, Local
  • Primary Myelofibrosis* / complications
  • Primary Myelofibrosis* / diagnosis
  • Primary Myelofibrosis* / therapy
  • Transplantation, Autologous


  • Bortezomib
  • Dexamethasone