Combination therapy with imiquimod and 5-fluorouracil cream for the treatment of actinic keratoses, a prospective open-label nonrandomized uncontrolled pilot trial

J Am Acad Dermatol. 2024 Jun;90(6):1247-1249. doi: 10.1016/j.jaad.2024.01.065. Epub 2024 Feb 3.

Authors

Richard Maxwell Regester¹, Amy C Cannella², Julianna Hirz³, Brian Sayles², Stacie Schlange², Amy Rau³, Harlan R Sayles², Anthony J Griess⁴

Affiliations

¹ University of Nebraska Medical Center, Omaha, Nebraska. Electronic address: rregester@unmc.edu.
² University of Nebraska Medical Center, Omaha, Nebraska.
³ Dermatology Specialists of Omaha, Omaha, Nebraska.
⁴ University of Nebraska Medical Center, Omaha, Nebraska; Dermatology Specialists of Omaha, Omaha, Nebraska.

PMID: 38316257
DOI: 10.1016/j.jaad.2024.01.065

No abstract available

Keywords: 5-fluorouracil; actinic keratoses; actinic keratosis; field cancerization; field therapy; imiquimod; squamous cell carcinoma.

Publication types

Letter
Clinical Trial

MeSH terms

Aged
Aged, 80 and over
Aminoquinolines / administration & dosage
Aminoquinolines / therapeutic use
Drug Therapy, Combination*
Female
Fluorouracil* / administration & dosage
Fluorouracil* / therapeutic use
Humans
Imiquimod* / administration & dosage
Imiquimod* / therapeutic use
Keratosis, Actinic* / drug therapy
Male
Middle Aged
Pilot Projects
Prospective Studies
Skin Cream / administration & dosage
Treatment Outcome