Orchestrating chromosome conformation capture analysis with Bioconductor

Nat Commun. 2024 Feb 5;15(1):1072. doi: 10.1038/s41467-024-44761-x.


Genome-wide chromatin conformation capture assays provide formidable insights into the spatial organization of genomes. However, due to the complexity of the data structure, their integration in multi-omics workflows remains challenging. We present data structures, computational methods and visualization tools available in Bioconductor to investigate Hi-C, micro-C and other 3C-related data, in R. An online book ( https://bioconductor.org/books/OHCA/ ) further provides prospective end users with a number of workflows to process, import, analyze and visualize any type of chromosome conformation capture data.

MeSH terms

  • Chromatin* / genetics
  • Chromosomes* / genetics
  • Genome
  • Molecular Conformation
  • Prospective Studies


  • Chromatin