Fixed-Duration Ibrutinib-Venetoclax for CLLAmong 211 patients with CLL who received ibrutinib-venetoclax or chlorambucil-obinutuzumab, there were 22 and 67 progression-free survival (PFS) events at a median follow-up of 27.7 months, respectively. PFS was significantly longer (P<0.001), and improvement with ibrutinib-venetoclax was consistent across subgroups. Adverse events (grade ≥3) were similar in both arms.