Osmotic Demyelination Syndrome in Patients Hospitalized with Hyponatremia

NEJM Evid. 2023 Apr;2(4):EVIDoa2200215. doi: 10.1056/EVIDoa2200215. Epub 2023 Mar 23.


Osmotic Demyelination Syndrome and HyponatremiaThe authors estimated the frequency of occurrence of osmotic demyelination syndrome (ODS) after correction of hyponatremia (i.e., serum sodium <130 mmol/l). Among 22,858 patients hospitalized for hyponatremia, there were 12 cases of ODS (0.05%). Correction of the serum sodium occurred in 3632 (17.7%) patients, less than one-half of the ODS cases.

MeSH terms

  • Demyelinating Diseases*
  • Humans
  • Hyponatremia*
  • Patients
  • Sodium


  • Sodium