Enlarged Perivascular Space in the Basal Ganglia is Associated with Cerebral Venous Reflux in Patients with Recent Small Subcortical Infarction

Zhengrong Wu; Ke Zhang; Ce Zong; Hongbing Liu; Yanhong Wang; Yuming Xu; Yuan Gao

doi:10.2174/0115672026299546240130092550

Enlarged Perivascular Space in the Basal Ganglia is Associated with Cerebral Venous Reflux in Patients with Recent Small Subcortical Infarction

Curr Neurovasc Res. 2024 Feb 7. doi: 10.2174/0115672026299546240130092550. Online ahead of print.

Authors

Zhengrong Wu¹, Ke Zhang¹, Ce Zong¹, Hongbing Liu¹, Yanhong Wang¹, Yuming Xu¹, Yuan Gao¹

Affiliation

¹ Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

PMID: 38323610
DOI: 10.2174/0115672026299546240130092550

Abstract

Background: Research has linked enlarged perivascular spaces (EPVS) to cerebral venous reflux (CVR) in patients with hypertensive intracerebral hemorrhage, but it is unclear whether this association exists in recent small subcortical infarct (RSSI) patients.

Objective: This study aimed to investigate the correlation between EPVS and CVR in patients with RSSI.

Method: This study included 297 patients, selected from patients with RSSI in the lenticulostriate artery admitted to the Department of Neurology of the First Affiliated Hospital of Zhengzhou University. CVR was assessed by time-of-flight magnetic resonance angiography (TOF-MRA). The relationship between EPVS and CVR was studied using multiple logistic regression analysis.

Results: This study included patients with an average age of 59.84±12.27 years, including 201 males (67.7%). CVR was observed in 40 (13.5%) patients. Compared to the group without CVR, the proportions of male patients and patients with a history of smoking and drinking were higher in the CVR group. The proportions of high-grade EPVS in the centrum semiovale region [23 cases (57.5%) vs. 108 cases (42.0%), p =0.067] and the basal ganglia region [30 cases (75.0%) vs. 133 cases (51.8%), p =0.006] were higher in the CVR group. After multiple logistic regression analysis, high-grade EPVS in the basal ganglia region was still associated with CVR (OR, 2.68; 95% CI, 1.22-5.87; p =0.014).

Conclusion: In the population with RSSI, EPVS in basal ganglia is significantly associated with CVR, suggesting a close relationship between venous dysfunction and the formation of EPVS.

Keywords: Recent small subcortical infarction; basal ganglia; cerebral small vessel disease; cerebral venous reflux; lenticulostriate artery territory.; perivascular space.